Symbol
Name
ID

Ebf1
early B cell factor 1
MGI:95275

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

increased B cell apoptosis

decreased B cell proliferation

enlarged spleen

decreased immature B cell number

decreased transitional stage B cell number

decreased pro-B cell number

arrested B cell differentiation

decreased germinal center B cell number

absent mature B cells

decreased B-1 B cell number

absent B-1 B cells

decreased B-2 B cell number

decreased marginal zone B cell number

increased B-1a cell number

increased B-1b cell number

decreased B cell number

decreased pre-B cell number

increased B cell number

decreased NK cell number

decreased effector memory CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased alpha-beta T cell number

increased T cell number

increased single-positive T cell number

increased osteoclast cell number

abnormal lymphocyte morphology

abnormal B cell morphology

abnormal spleen morphology

small spleen

decreased spleen germinal center number

abnormal germinal center B cell physiology

decreased IgD level

decreased IgG1 level

decreased IgG3 level

decreased IgM level

increased IgM level

abnormal lymph node morphology

enlarged lymph nodes

abnormal humoral immune response

increased tumor necrosis factor secretion

Availability

Mouse Genotype

Ebf1^m1Btlr/Ebf1^m1Btlr

Ebf1^m2Btlr/Ebf1^m2Btlr

Ebf1^M3Btlr/Ebf1^M3Btlr

Ebf1^M4Btlr/Ebf1^M4Btlr

Ebf1^M5Btlr/Ebf1^M5Btlr

Ebf1^m6Btlr/Ebf1^m6Btlr

Ebf1^tm1Rug/Ebf1^tm1Rug

Ebf1^em1(IMPC)Mbp/Ebf1⁺

Ebf1^tm1.1Rug/Ebf1^tm1.1Rug
Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ (conditional)

Ebf1^tm1.1Rug/Ebf1^tm1.1Rug
Cd79a^tm1(cre)Reth/Cd79a⁺ (conditional)

Ebf1^tm1.1Rug/Ebf1^tm1.1Rug
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Ebf1^tm1.1Rug/Ebf1^tm1.1Rug
Tg(Cr2-cre)3Cgn/0 (conditional)

Ebf1^tm1.1Rug/Ebf1^tm1.1Rug
Ighg1^tm1(cre)Cgn/Ighg1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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